Apo A-I is a protein that plays a role in the metabolism of lipids and is one of the main components attached to HDL, commonly referred to as the “good cholesterol”. HDL plays a very important role in removing excess cholesterol from cells and takes it to the liver for recycling or disposal.
Levels of apo A-I is directly proportional to HDL levels in the blood, and deficiencies in apo A-I correlate with an increased risk of developing CVD.
Like Apo-lipoprotein A1, Apo B is also a protein that is involved in the metabolism of lipids and is the main protein constituent of lipoproteins such as very low-density lipoprotein (VLDL) and low-density lipoprotein (LDL, the “bad cholesterol”). Concentrations of apo B is directly proportional to LDL-C. Doctors usually order both an apo A-I (associated with high-density lipoprotein (HDL), the “good” cholesterol) and an apo B to determine an apo B/apo A-I ratio. This ratio is used as an alternative to a total cholesterol/HDL ratio to evaluate risk for developing CVD.
Apo B levels may be ordered to monitor the effectiveness of lipid treatment as an alternative to non-HDL-C (non-HDL-C is the total cholesterol concentration minus the amount of HDL).
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