CH50 (Complement, Total)
The complement system helps or “complements” the ability of antibodies and phagocytic cells to clear pathogens from an organism. It is part of the immune system. The complement system comprises of proteins that is produced by the liver.
The complement system has the potential to be extremely damaging to host tissues and its activation must be tightly regulated. The complement system is regulated by complement control proteins, which are present at a higher concentration in the blood plasma than the complement proteins themselves.
The test is best used to
SCREEN complement deficiency associated Immunodeficiency (primarily classic or terminal complement component deficiencies)
DETECT congenital and acquired severe deficiency disorders of the primary complement pathway
MONITOR the progress of patients with immune complex disease like Systemic Lupus Erythematosus (SLE)
The test is recommended when a person has recurrent infections, unexplained swellings (angioedema), inflammation, to diagnose & monitor activity of chronic autoimmune disorders such as SLE and to monitor other immune complex- related diseases and conditions such as serum sickness, and some cases of rheumatoid arthritis, glomerulonephritis, and vasculitis
|Related Tests||ESR; C-Reactive Protein; Rheumatoid Factor; ANA; Autoantibodies|